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Biostatistics Seminar: “Omics” Perspectives on Childhood Obesity
November 13, 2019 @ 12:00 pm - 1:00 pm
Francesca Chiaromonte, PhD, Dorothy Foehr Huck and J. Lloyd Huck Chair in Statistics for the Life Sciences, and Director, Institute for Genome Sciences, Penn State, will present “‘Omics’ Perspectives on Childhood Obesity” at an upcoming biostatistics seminar.
Childhood obesity is a growing epidemic with an enormous societal impact. As part of an ongoing collaboration with the INSIGHT and SIBSIGHT projects led by Dr. Ian Paul and colleagues at Penn State Health Milton S. Hershey Medical Center, Dr. Chiaromonte’s group focused on analyzing a variety of “omics” data collected from children and their mothers. These included gut and oral microbiota, genetic variants and fecal metabolomes – along with important clinical, behavioral and environmental covariates. Notwithstanding the relatively small sample size of the study, the group was able to leverage a number of statistical techniques for handling high-dimensional predictors and functional response variables (in this case, the growth curves of children sampled over the first three years after birth) to identify significant “omics” risk signatures associated with weight gain in early life. In this talk, Dr. Chiaromonte will briefly survey the analysis approaches and results.
This is joint work with Drs. Sarah Craig and Kateryna Makova (Department of Biology), Anna Kenney and Matthew Reimherr (Department of Statistics) and many other colleagues across Penn State.
Light refreshments will be served.