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Biostatistics seminar: “Sample Size Re-estimation: A Cautionary Tale”

December 12, 2019 @ 12:00 pm - 1:00 pm

“Sample Size Re-estimation: A Cautionary Tale” will be presented by Leslie McClure, PhD, Professor and Chair, Department of Epidemiology and Biostatistics, Drexel School of Public Health.

The use of adaptive designs has been increasing in randomized clinical trials. Sample size re-estimation is a type of adaptation in which nuisance parameters are estimated at an interim point in the trial and the sample size re-computed based on these estimates. However, post-hoc evaluations of adaptations, including sample size re-estimations, have not frequently been performed, leaving questions about the gains that come from utilizing these procedures in practice. In this talk, Dr. McClure will describe the statistical impact of implementing a sample size re-estimation in the Secondary Prevention of Small Subcortical Strokes (SPS3) study and describe the effect of the adaptation on the practical aspects of the study.

Light refreshments will be served.

Participants may join the seminar by calling 669-900-6833, meeting ID 322043373, or via Zoom.


December 12, 2019
12:00 pm - 1:00 pm
Event Category:


Department of Public Health Sciences


Academic Support Building (ASB) Room 2200G
90 Hope Drive
Hershey, PA 17033 United States
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