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Webinar: Biostatistics and Bioinformatics Seminar – ‘A Bayesian Phase I/II Trial Design for Immunotherapy’

September 22, 12:00 pm to 1:00 pm

Presented by: Suyu Liu, PhD, Associate Professor, Department of Biostatistics, Division of Basic Sciences, The University of Texas MD Anderson Cancer Center

About the presentation: Immunotherapy is an innovative treatment approach that stimulates a patient’s immune system to fight cancer. It demonstrates characteristics distinct from conventional chemotherapy and stands to revolutionize cancer treatment. We propose a Bayesian phase I/II dose-finding design that incorporates the unique features of immunotherapy by simultaneously considering three outcomes: immune response, toxicity and efficacy. The objective is to identify the biologically optimal dose, defined as the dose with the highest desirability in the risk-benefit tradeoff.  An Emax model is utilized to describe the marginal distribution of the immune response. Conditional on the immune response, we jointly model toxicity and efficacy using a latent variable approach. Using the accumulating data, we adaptively randomize patients to experimental doses based on the continuously updated model estimates. A simulation study shows that our proposed design has good operating characteristics in terms of selecting the target dose and allocating patients to the target dose.

To join by Zoom, visit: https://pshealth.zoom.us/j/96786475339

To join by phone, dial 929-205-6099

Passcode to enter seminar:  013520

Meeting ID:  967 8647 5339

Details

Date:
September 22
Time:
12:00 pm to 1:00 pm
Event Category:
Website:
https://pshealth.zoom.us/j/96786475339

Organizer

Department of Public Health Sciences
Email:
pennstatepublichealth@phs.psu.edu
View Organizer Website

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