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Webinar: Biostatistics and Bioinformatics Seminar – Understanding the Polygenic Architecture and Regulatory Mechanisms of Human Complex Traits
February 25, 9:00 am to 10:00 am
“Understanding the Polygenic Architecture and Regulatory Mechanisms of Human Complex Traits” will be presented by Jian Yang, PhD, professor in the School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.
Most common traits (including diseases) in humans are influenced by many genetic variants with small effects. This pattern of genetic architecture is often referred to as the polygenic model. Understanding the causes of polygenic architecture and the molecular mechanisms underlying the polygenic effects have important implications in human health and evolution. In this talk, Dr. Yang will discuss the use of mixed linear models that fit the effects of all genetic variants available in a genome-wide association study (GWAS) as random effects to estimate genetic architecture parameters for a complex trait (e.g., the overall contribution of the polygenic effects to the trait, and the proportion of variants with non-zero effects), and the use of genetic architecture parameters to infer the evolutionary causes of polygenic architecture. Dr. Yang will then demonstrate methods and analyses that integrate data from GWASs of complex traits and other molecular phenotypes (e.g., gene expression and DNA methylation) to predict putative causal genes and regulatory mechanisms underpinning the polygenic effects on complex traits. Dr. Yang will further present two resource-efficient tools for MLM-based association analysis in biobank-scale data.
Participants may also join by calling 929-205-6099, meeting ID 322 043 373. If prompted, enter passcode 167660.