Topics: Core Facilities

Focused ion beam scanning electron microscopy reveals a previously unknown complex formed at cell-to-cell junctions consisting of desmosomes, keratin filaments and endoplasmic reticulum.

Advanced imaging gives researchers front row view of cellular junctions

Oct 19, 2023

Penn State College of Medicine researchers used focused ion beam scanning electron microscopy to reveal a previously unknown complex formed at cell-to-cell junctions consisting of desmosomes, keratin filaments and endoplasmic reticulum.

Images show fibrinogen molecules absorbed on a surface and imaged in buffer. A graph also depicts the force curve of the strength of the molecular interaction as well as mechanical properties of the cell.

NIH Instrumentation Grant to enhance College of Medicine Atomic Force Microscopy Core

Sep 27, 2023

Atomic Force Microscopy is a biophysical method available to College of Medicine researchers that allows topological, nanomechanical and biophysical data of biological hydrated samples including cells or tissues.

Microglia are stained immunohistochemically and viewed using microscopy.

Core Facilities highlights Metabolic Phenotyping Core

Feb 15, 2023

In their monthly spotlight, the Core Facilities recognized work from the laboratories of Amy Arnold, PhD, and Yuval Silberman, PhD, which utilized the services of the Metabolic Phenotyping Core.

The Nittany Lion statue in the Hershey Medical Center courtyard is surrounded by snow, behind it, several trees and part of the Hershey Medical Center building are visible.

Genome Sciences core introduces new technologies

Jan 19, 2023

The Genome Sciences Core facility announces that leading edge technologies, including single cell multiomics and spatial transcriptomics, are now available.

Twelve images of melanoma cells captured from an imaging cytometer are shown in a figure.

Flow cytometry helps unveil Schweinfurthins’ unique strategy for exposing melanoma cells

Dec 19, 2022

A derivative of the family of natural products called schweinfurthins uniquely induce cancer cell death, according to a Penn State College of Medicine and Penn State Cancer Institute research study.

Sanjib Adhikary and Joan Gensamer stand beside each other holding their award trophies.

Research and Innovation Awards highlight faculty, staff, student achievements

Oct 13, 2022

Penn State College of Medicine faculty, staff and students celebrated their peers’ research achievements at the Research and Innovations Awards on Oct. 12.

A whole, live cell image of a neuron expressing fluorescently tagged actin and cofilin.

Multiscale imaging confirms protein’s role in neuronal structure and dynamics

Jun 13, 2022

College of Medicine researchers found in a new study that a long-observed protein structure called cofilactin was shown to play a major role in neuronal structure and dynamics.

A woman holds a bottle of medication

Unsung heroes: Core Facilities and Research Resources key to COVID-19 research at College of Medicine

Jan 9, 2022

Penn State College of Medicine faculty continue to perform leading-edge COVID-19 studies, and one reason why is the College of Medicine Core Facilities and Research Resources team. Researchers are investigating […]

A head and shoulders professional portrait of Bruce Stanley against a background image of Penn State College of Medicine.

Stanley, ‘scientific head of core facilities’ at College of Medicine, retiring after 35 years

Dec 14, 2021

Dr. Bruce Stanley, director of the Core Facilities Research Resources at the College of Medicine, is retiring after 35 years of service.

Illustrations of the ATP13A2 protein in six different color schemes. A handful of the illustrations show a narrow channel used for polyamine transport.

Fit for a polyamine: microscopy opens doors for studying neurodegenerative disease

Nov 29, 2021

College of Medicine researcher Kenneth Lee is using cryogenic electron microscopy to study the structure of a particular protein with the hopes of developing new therapeutic approaches for neurodegenerative diseases.

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