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PHS Biostatistics and Bioinformatics Seminar by Dr. Yukinori Okada, MD, PhD, Professor, Department of Genome Informatics, The University of Tokyo
February 7, 8:00 am to 9:00 am
PHS Biostatistics and Bioinformatics Seminar presented by Dr. Yukinori Okada, MD, PhD, Professor, Department of Genome Informatics, The University of Tokyo
Statistical genetics is a research field that evaluates causality of human genetic variations on diseases, using statistical and bioinformatics approaches. Recent developments of sequencing technologies have provided human disease genome data of hundreds of thousands of the subjects, and successfully identified comprehensive catalogues of genetic susceptible loci. However, little is known regarding how to develop methodology to integrate large-scale human genome data with diverse biological resources. We have developed such methods and applied to a pioneering example of large-scale genetic association studies on a variety of human complex traits. Tran-layer omics analysis identified the cell types and microbiomes implicated in disease biology. Network analysis between the disease risk genes and the drug target genes could identify novel candidates of drug repositioning. Integration of cell type-specific gene expression profiles estimated from GWAS with compound perturbation databases can pinpoint novel therapeutic targets and compounds. Application of the machine learning methods into population genome data can classify the samples without prior biological information. These results should empirically show the value of statistical genetics to dissect disease biology, novel drug discovery, and personalized medicine. Finally, we would like to introduce our activity on young researcher developments (“Summer school of statistical genetics”).
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