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Cores offer preview of new technologies

Penn State College of Medicine has recently acquired or is currently acquiring several new high-end instrumentation systems.

More information about these instruments will be shared in future news posts and editions of the core facilities email newsletter.

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iThera MSOT 512 Photoacoustic Imaging

Location: Central Animal Quarters (CAQ)

This in vivo small-animal ultrasound and optoacoustic imaging instrument provides:

  • Ultrasound-based anatomical contrast of entire mouse/rodents
  • Optoacoustic-based functional contrast, such as vascular structure, oxygen saturation and tissue metabolism
  • Biomarker-targeted molecular contrast using various optoacoustic contrast agents, such as nanoparticles and small molecules

BD FACSymphony A3 Flow Cytometer

Location: Room C3607

This state-of-the-art flow cytometric cell analyzer enables the simultaneous measurement of up to 25 different characteristics of a single cell, including the detection of parameters in the ultraviolet range. This high-parameter and highly sensitive flow cytometer enables scientists to identify and quantify distinctive phenotypes in heterogeneous populations of cells or particles.

Miltenyi Biotec Ultramicroscope II Light Sheet Fluorescent Microscopy

Location: Room C1733A

This system is designed for imaging cleared samples, such as mouse brain, and intrinsically transparent in vivo samples, such as zebrafish. A distinct advantage of the system over conventional point-scanning systems, like confocal microscopy, includes rapid acquisition of large 3D volume at micron resolution with plane beam illumination.

Leica SP8 microscope with FCS/FLIM capabilities

Location: Room C1733

Confocal fluorescence correlation spectroscopy is a single-molecule detection technique that enables determination of molecular sizes, aggregation states, binding and biochemical kinetics, in vitro and in vivo. Confocal-based fluorescence lifetime imaging enables precise measurements of fluorescence resonance energy transfer; redox species, such as oxidized forms of flavin adenine dinucleotide, bound vs. unbound; and other endogenous fluorescent compounds. This combined platform also enables 3D confocal imaging and ultra-fast deconvolution of 3D confocal images.

Zeiss LSM 980 Cryo Spectral Confocal Microscope With AiryScan 2

Location: Room C1733

The LSM 980 provides the latest in Airyscan 2 technology from Zeiss Instruments, which can achieve 120-nm resolution with any fluorescent tag. Its exceptional sensitivity allows for minimal laser intensities, and it is equipped with a piezoelectric stage for extremely fast Z-stacks. This microscope is also equipped with a Linkam cryostage, which allows for correlative cryo-fluorescence and cryo-electron microscopic imaging in conjunction with the new Titan Krios TEM.

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